• Login
    View Item 
    •   UZ eScholar Home
    • Faculty of Science
    • Department of Biochemistry
    • Biochemistry Staff Publications
    • View Item
    •   UZ eScholar Home
    • Faculty of Science
    • Department of Biochemistry
    • Biochemistry Staff Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Proportions of CD41 memory T cells are altered in individuals chronically infected with Schistosoma haematobium

    Thumbnail
    View/Open
    Nausch_et_al_Proportions_of_CD41_memory_T_cells.pdf (676.5Kb)
    Date
    2012-06-26
    Author
    Bourke, Claire D.
    Appleby, Laura J.
    Rujeni, Nadine
    Lantz, Olivier
    Trottein, François
    Midzi, Nicholas
    Nausch, Norman
    Mduluza, Takafira
    Mutapi, Francisca
    Type
    Article
    Metadata
    Show full item record

    Abstract
    Characterisation of protective helminth acquired immunity in humans or experimental models has focused on effector responses with little work conducted on memory responses. Here we show for the first time, that human helminth infection is associated with altered proportions of the CD41 memory T cells, with an associated alteration of TH1 responses. The reduced CD41memory T cell proportions are associated with a significantly lower ratio of schistosome-specific IgE/IgG4 (marker for resistance to infection/re-infection) in uninfected older people. Helminth infection does not affect the CD81memory T cell pool. Furthermore, we show for the first time in a helminth infection that the CD41 memory T cell proportions decline following curative anti-helminthic treatment despite increased CD41 memory cell replication. Reduced accumulation of the CD41 memory T cells in schistosome-infected people has implications for the development of natural or vaccine induced schistosome-specific protective immunity as well as for unrelated pathogens.
    URI
    http://hdl.handle.net/10646/3094
    Additional Citation Information
    Nausch, N. et al. Proportions of CD41 memory T cells are altered in individuals chronically infected with Schistosoma haematobium. Sci. Rep. 2, 472; DOI:10.1038/srep00472 (2012).
    Sponsor
    World Health Organisation (Grant no RPC264), the Wellcome Trust (Grant no WT082028MA) and by Thrasher Research Funds
    Publisher
    Nature Publishing Group
    Subject
    Helminth infection
    the CD41 memory T cells
    TH1 responses
    schistosome infections
    Collections
    • Biochemistry Staff Publications [10]

    University of Zimbabwe: Educating To Change Lives!
    DSpace software copyright © 2002-2020  DuraSpace | Contact Us | Send Feedback
     

     

    Browse

    All of UZ eScholarCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    View Usage StatisticsView Google Analytics Statistics

    University of Zimbabwe: Educating To Change Lives!
    DSpace software copyright © 2002-2020  DuraSpace | Contact Us | Send Feedback