Comparison of In Vitro bioavailability of proprietary propranolol preparations

Abstract

Dissolution rate studies were conducted to compare the release rate of propranolol from two proprietary preparations. Propranolol was released at a faster rate from Rexigen* when compared to Inderal* which suggests that plasma levels of the drug would be higher in patients taking the former preparation. Both preparations showed satisfactory dissolution but problems may be encountered if a patient stabilized on one brand were to change to the other.