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dc.creatorEssien, E.U.
dc.date.accessioned2015-09-15T11:38:52Z
dc.date.accessioned2015-12-08T10:56:12Z
dc.date.available2015-09-15T11:38:52Z
dc.date.available2015-12-08T10:56:12Z
dc.date.created2015-09-15T11:38:52Z
dc.date.issued1994-08
dc.identifierEssien, E.U. (1994) Increased susceptibility of erythrocyte membrane lipids to peroxidation in sickle cell disease. The Central African Journal of Medicine (CAJM), vol. 40, no.8, (pp. 217-220). UZ, Avondale, Harare: Faculty of Medicine (UZ).
dc.identifier0008-9176
dc.identifierhttp://opendocs.ids.ac.uk/opendocs/handle/123456789/7049
dc.identifier.urihttp://hdl.handle.net/10646/2507
dc.description.abstractErythrocytes from normal subjects and from cases of sickle cell disease were exposed to hydrogen peroxide and the extent of membrane lipid peroxidation studied. Significantly increased peroxidation was observed in intact erythrocytes, isolated lipids from intact erythrocytes or their ghosts compared with normal controls. However, the extent of lipid peroxidation was less for isolated lipids of intact erythrocytes or their ghosts. This difference may be due to loss of factors enhancing peroxidation in intact erythrocytes in the extraction procedure. It is likely that damage to erythrocyte membranes caused by increased susceptibility to lipid peroxidation may be a factor in some of the haematological features of sickle cell disease.
dc.languageen
dc.publisherFaculty of Medicine, Central African Journal of Medicine (CAJM) University of Zimbabwe (UZ.)
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.rightsUniversity of Zimbabwe (UZ)
dc.subjectHealth
dc.titleIncreased susceptibility of erythrocyte membrane lipids to peroxidation in sickle cell disease
dc.typeArticle
dc.typeSeries paper (non-IDS)


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