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dc.contributor.authorChirove, Faraimunashe
dc.date.accessioned2012-08-31T06:52:41Z
dc.date.available2012-08-31T06:52:41Z
dc.date.issued2012-08-31
dc.identifier.urihttp://hdl.handle.net/10646/930
dc.description.abstractTreatment with antiretroviral drugs has been reported to delay progression of HIV infection to AIDS, and may even lower the infectiousness of the infectives. This study investigates the effects of treatment of HIV-1 with Reverse Transcriptase Inhibitors (RTI's) and Protease Inhibitors (PI's) at cellular level. A threshold parameter, Ncrit, which determines the outcome of the infection, is established.If NT < Ncrit, the infection dies out, while if Ncrit < NT, the infection persists where NT is the number of virions produced by each infected CD4+_T cell. The steady states are determined for the models under study. Numerical simulations are presented to illustrate the stability of the endemic steady states.en_ZW
dc.language.isoen_ZWen_ZW
dc.subjectvirus cellsen_ZW
dc.subjectmathematical modelsen_ZW
dc.subjectprotease inhibitorsen_ZW
dc.subjectreverse transcriptase inhibitorsen_ZW
dc.subjectHIV-1en_ZW
dc.subjecttreatmenten_ZW
dc.subjectAIDSen_ZW
dc.titleTreatment of HIV-1 with Reverse Transcriptase Inhibitors ( RTI's) and Protease Inhibitors ( PI's )en_ZW
thesis.degree.advisorLungu, E. M. (Prof.)
thesis.degree.countryZimbabween_ZW
thesis.degree.disciplineMathematicsen_ZW
thesis.degree.facultyFaculty of Scienceen_ZW
thesis.degree.grantorUniversity of Zimbabween_ZW
thesis.degree.grantoremailspecialcol@uzlib.uz.ac.zw
thesis.degree.levelMScen_ZW
thesis.degree.nameMaster of science in Mathematicsen_ZW
thesis.degree.thesistypeThesisen_ZW
dc.date.defense2005-06-30


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