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Recent Submissions
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Estimating HIV incidence over a decade in Zimbabwe: A comparison of the catalytic and Farrington models
(PLOS Global Public Health, 2023-09-14)Over the years, numerous modelling studies have been proposed to estimate HIV incidence. As a result, this study aimed to evaluate two alternative methods for predicting HIV incidence in Zimbabwe between 2005 and 2015. We ... -
Predicting HIV infection in the decade (2005–2015) pre-COVID-19 in Zimbabwe: a supervised classification-based machine learning approach
(PLOS Digital Health, 2023-06-07)The burden of HIV and related diseases have been areas of great concern pre and post the emergence of COVID-19 in Zimbabwe. Machine learning models have been used to predict the risk of diseases, including HIV accurately. ... -
Factors Associated With HIV Infection in Zimbabwe Over a Decade From 2005 to 2015: An Interval-Censoring Survival Analysis Approach
(Frontiers in Public Health, 2019-09-18)Objectives: The main objective of this study was to compare results from two approaches for estimating the effect of different factors on the risk of HIV infection and determine the best fitting model. Study design: We ... -
Estimating age specific prevalence and force of infection in Zimbabwe using combined cross-sectional surveys from 2005 to 2015
(Frontiers in epidemiology, 2022-12-06)Objective: Age structured sexual mixing patterns have been noted to be associated with HIV prevalence and force of infection. Therefore, this study aimed to estimate the age dependent HIV force of infection using survey ... -
Effect of Schistosoma haematobium infection on the cognitive functions of preschool age children and benefits of treatment from an endemic area in Zimbabwe
(BMC Infectious Diseases, 2022-10-31)Background Schistosomiasis is known to affect the cognitive functions of children, however, but there is paucity of information on its impact on early childhood development in developing countries where the disease is ... -
Proportions of CD41 memory T cells are altered in individuals chronically infected with Schistosoma haematobium
(Nature Publishing Group, 2012-06-26)Characterisation of protective helminth acquired immunity in humans or experimental models has focused on effector responses with little work conducted on memory responses. Here we show for the first time, that human ... -
Release of 7-methyIguanine residues whose imidazole rings have been opened from damaged DNA by a DNA glycosylase from Escherichia coli
(Oxford University Press, 1979-05)Double-stranded DNA containing 7-methylguanine residues whose imidazole rings have been opened, i.e. 2, 6-diamino-4-hydroxy-5—N-methylformamidopyrimidine residues, may be prepared by treatment of DNA with dimethyl sulphate ... -
Immunological consequences of antihelminthic treatment in preschool children exposed to urogenital schistosome infection
(Hindawi Publishing Corporation, 2013-05-13)Urogenital schistosomiasis, due to Schistosoma haematobium, is endemic in sub-Saharan Africa. Control is by targeted treatment with praziquantel but preschool age children are excluded from control programs. Immunological ... -
Regulatory and Activated T cells in human schistosoma haematobium infections
(PLoS One, 2011-02-10)Acquired immunity against helminths is characterised by a complex interplay between the effector Th1 and Th2 immune responses and it slowly manifests with age as a result of cumulative exposure to parasite antigens. Data ... -
Group 2 Innate Lymphoid Cell Proportions Are Diminished in Young Helminth Infected Children and Restored by Curative Antihelminthic Treatment
(PLoS, 2015-03-20)Group 2 Innate lymphoid cells (ILC2s) are innate cells that produce the TH2 cytokines IL-5 and IL-13. The importance of these cells has recently been demonstrated in experimental models of parasitic diseases but there is ... -
Effect of treating Schistosoma haematobium infection on Plasmodium falciparum-specific antibody responses
(BioMed Central, 2008-11-17)The overlapping geographical and socio-economic distribution of malaria and helminth infection has led to several studies investigating the immunological and pathological interactions of these parasites. This study focuses ... -
Efficacy of integrated school based de-worming and prompt malaria treatment on helminths -Plasmodium falciparum co-infections: A 33 months follow up study
(BioMed Central, 2011)The geographical congruency in distribution of helminths and Plasmodium falciparum makes polyparasitism a common phenomenon in Sub Saharan Africa. The devastating effects of helminths-Plasmodium co-infections on primary ... -
Knowledge attitudes and practices of grade three primary school children in relation to schistosomiasis, soil transmitted helminthiasis and malaria in Zimbabwe
(BioMed Central, 2011)Helminth infection rates in grade three children are used as proxy indicators of community infection status and to guide treatment strategies in endemic areas. However knowledge, attitudes and practices (KAP) of this target ... -
Downregulation of MIP-1α/CCL3 with praziquantel treatment in Schistosoma haematobium and HIV-1 co-infected individuals in a rural community in Zimbabwe
(BioMed Central, 2009-10-23)Chemokines have been reported to play an important role in granulomatous inflammation during Schistosoma mansoni infection. However there is less information on their role in Schistosoma haematobium infection, or on the ... -
Identifying and evaluating field indicators of Urogenital Schistosomiasis-related morbidity in preschool-aged children
(PLOS, 2015-03-20)Several studies have been conducted quantifying the impact of schistosome infections on health and development in school-aged children. In contrast, relatively little is known about morbidity levels in preschool-aged ...
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