Please use this identifier to cite or link to this item: https://hdl.handle.net/10646/2507
Title: Increased susceptibility of erythrocyte membrane lipids to peroxidation in sickle cell disease
Keywords: Health
Issue Date: Aug-1994
Publisher: Faculty of Medicine, Central African Journal of Medicine (CAJM) University of Zimbabwe (UZ.)
Abstract: Erythrocytes from normal subjects and from cases of sickle cell disease were exposed to hydrogen peroxide and the extent of membrane lipid peroxidation studied. Significantly increased peroxidation was observed in intact erythrocytes, isolated lipids from intact erythrocytes or their ghosts compared with normal controls. However, the extent of lipid peroxidation was less for isolated lipids of intact erythrocytes or their ghosts. This difference may be due to loss of factors enhancing peroxidation in intact erythrocytes in the extraction procedure. It is likely that damage to erythrocyte membranes caused by increased susceptibility to lipid peroxidation may be a factor in some of the haematological features of sickle cell disease.
URI: http://hdl.handle.net/10646/2507
Other Identifiers: Essien, E.U. (1994) Increased susceptibility of erythrocyte membrane lipids to peroxidation in sickle cell disease. The Central African Journal of Medicine (CAJM), vol. 40, no.8, (pp. 217-220). UZ, Avondale, Harare: Faculty of Medicine (UZ).
0008-9176
http://opendocs.ids.ac.uk/opendocs/handle/123456789/7049
Appears in Collections:Social Sciences Research , IDS UK OpenDocs

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