Cross sectional sero-epidemiological prevalence of poliovirus antibodies post immunization with three doses of TOPV

Abstract

A cross-sectional sero epidemiological study to detect the presence of antibodies to polio virus types 1,2 and 3 was undertaken. A total of 437 infants with an average of 40 subjects per province was enrolled in this study. All the subjects had completed the three doses of TOPV. Blood samples were aseptically collected by heel pricking on calibrated filter papers and immediately transported to the laboratory for processing. In the laboratory, standardized techniques were used to detect neutralizing antibodies to polio virus. Antibodies with a titre of 1:32 were detected in all studied subjects. Some infants developed litres as high as 1:1024. However, polio virus type 3 showed a higher antibody titre than the other two types. Differences in titres were observed from province to province.