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    Assessing the impact of drug resistance on the transmission dynamics of Typhoid fever.

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    Date
    2013-05-20
    Author
    Mushayabasa, Steady
    Bhunu, Claver P.
    Ngarakana-Gwasira, Ethel T.
    Type
    Article
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    Abstract
    Typhoid fever continues to be a major public health problem in the developing world. Antibiotic therapy has been the main stay of treating typhoid fever for decades. The emergence of drug-resistant typhoid strain in the last two decades has been a major problem in tackling this scourge. A mathematical model for investigating the impact of drug resistance on the transmission dynamics of typhoid fever is developed. The reproductive number for the model has been computed. Numerical results in this study suggest that when a typhoid outbreak occurs with more drug-sensitive cases than drug-resistant cases, then it may take 10–15 months for symptomatic drug-resistant cases to outnumber all typhoid cases, and it may take an average of 15–20 months for non symptomatic drug-resistant cases to outnumber all drug-sensitive cases.
    URI
    https://hdl.handle.net/10646/4016
    Additional Citation Information
    Mushayabasa, S., Bhunu, C. P., & Ngarakana-Gwasira, E. T. (2013). Assessing the impact of drug resistance on the transmission dynamics of typhoid fever. Computational Biology Journal, Vol 2013.
    Publisher
    Hindawi
    Subject
    Typhoid fever
    Typhoid
    Antibiotic therapy
    drug-resistant typhoid
    reproductive number
    Collections
    • Department of Mathematics Staff Publications [14]

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