Low risk and high risk human papillomaviruses (HPVs) and cervical cancer in Zimbabwe: Epidemiological evidence
Stanczuk, G. A.
Tswana, S. A.
Nzara, M. J.
Moyo, S. R.
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Objective: To establish the prevalence of detectable low-risk and high-risk, oncogenic HPV types in cervical swabs of women with histologically proven cancer of the cervix. Design: Cross sectional study. Setting: Harare Central and Parirenyatwa Hospitals. Subjects: 119 women with histologically proven cervical cancer of whom 63 had the degree of differentiation of the tumour reported. Main Outcome Measures: Frequency of infection with high and low-risk human papillomaviruses. Results: The presence of HPV DN A was demonstrated in 63% (75/119) of cases. Low risk HPVs were present in 26% (31/119) and high-risk HP Vs were demonstrated in 51% (61/119) of samples tested. Co-infection with both low-risk and high-risk HPVs was observed in 14% (17/119) of the specimens. High-risk HPVs were detected in 55% (21/38) of poorly differentiated tumours while 60% (15/25) of moderately and well- differentiated tumours showed the presence of high-risk HPVs. Conclusion: High-risk human papillomaviruses are associated with cervical cancer. There was no significant difference in the frequency of high-risk HPV types in women with moderately to well-differentiated tumours and those with poorly-differentiated tumors.
Additional Citation InformationChirara, M., Stanczuk, G. A., Tswana, S. A., Bergstrom, S., Moyo, S. R. & Nzara, M. J. (2001). Low risk and high risk human papillomaviruses (HPVs) and cervical cancer in Zimbabwe: Epidemiological evidence, Central African Journal of Medicine, 47 (2), 32-35.
University of Zimbabwe, College of Health Sciences