• Login
    View Item 
    •   UZ eScholar Home
    • Faculty of Medicine and Health Sciences
    • Faculty of Medicine and Health Sciences ETDs
    • Faculty of Medicine & Health Sciences e-Theses Collection
    • View Item
    •   UZ eScholar Home
    • Faculty of Medicine and Health Sciences
    • Faculty of Medicine and Health Sciences ETDs
    • Faculty of Medicine & Health Sciences e-Theses Collection
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Renal dysfunction in HIV positive patients on highly active antiretroviral therapy (HAART)

    Thumbnail
    View/Open
    Maramba._Renal_dysfunction_in_HIV_positive_patients_on_Highly_Active_AntiretroviralTherapy_pdf.pdf (807.6Kb)
    Date
    2016-11
    Author
    Maramba, Patience Julia
    Metadata
    Show full item record

    Abstract
    BACKGROUND: The use of HAART has turned HIV/AIDS into a chronic disease and people live longer. They now present with complications related to the treatment, ageing process and the virus itself. Renal dysfunction is a recognized complication in HIV infected patients on HAART and can present as acute kidney injury or chronic kidney disease. METHODS: A cross sectional study was conducted at Parirenyatwa Hospital on patients receiving HAART. Inclusion criteria were age ≥ 18 years and provision of an informed consent. Clinical data was recorded. Body mass index, CD4 count, serum creatinine, urine for dipstick proteinuria and protein: creatinine ratio was collected. Creatinine was calculated using the Cockcroft-Gault formula. Renal dysfunction was defined as Creatinine clearance (CrCl)< 60mL/min. RESULTS: A total of 122 patients with complete data were analysed. 69% were females. Mean age of patients was 37.7 ±11.3 years and Body mass index was26.0 ±5.2 kg/m². Renal dysfunction defined as CrCl< 60mL/min was found in 18.9 %,(n =23/122). Microalbuminuria was found to be a risk factor for renal dysfunction [OR 4.24 95% CI 1.00-17.04] p < 0.049. CONCLUSION: Renal dysfunction is common among patients on HAART and micro albuminuria is a risk factor for developing renal dysfunction. For patients on HAART routine urine protein: creatinine ratio and calculation of creatinine clearance should be done at regular intervals to monitor if the patients are developing renal dysfunction.
    URI
    http://hdl.handle.net/10646/2894
    Subject
    Renal Dysfunction
    Renal Insufficiency
    HIV positive patients
    Collections
    • Faculty of Medicine & Health Sciences e-Theses Collection [158]

    University of Zimbabwe: Educating To Change Lives!
    DSpace software copyright © 2002-2020  DuraSpace | Contact Us | Send Feedback
     

     

    Browse

    All of UZ eScholarCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    View Usage StatisticsView Google Analytics Statistics

    University of Zimbabwe: Educating To Change Lives!
    DSpace software copyright © 2002-2020  DuraSpace | Contact Us | Send Feedback