Occurrence of diabetogenic changes in pregnancy among black women in an urban setting
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Objective: To find out if pregnancy in black Zimbabwean women is a diabetogenic state using basal blood levels of cortisol, insulin, C-peptide and glucose. Methods: 111 women (28 non-pregnant, 29 first trimester, 26 second trimester and 28 third trimester) aged between 18 and 35 years were recruited for the study. Fasting plasma cortisol, insulin, C-peptide and glucose were determined by standard methods. The glucose/insulin ratio was used as an index of insulin sensitivity and the C-peptide/glucose ratio as well as the homeostasis assessment model (HOMA) as an index of insulin resistance. Results: The means of fasting plasma cortisol levels were significantly elevated, p <0.0001 among the four groups (non-pregnant, first, second and third trimester women). Fasting plasma insulin levels peaked during the third trimester and significant differences were noted among all women, p <0.05. Similar data was obtained for C-peptide levels (a better indicator of beta-cell insulin secretory activity) among the groups, p <0.01. The means of fasting plasma glucose levels were significantly decreased with advancing gestation, p <0.0001. Significantly lower glucose/insulin ratios, a measure of insulin sensitivity and elevated C-peptide/glucose ratios, an index of insulin resistance, were demonstrated among the women, (p <0.05 and <0.01 respectively). Conclusion: The basal data presented in this paper clearly demonstrates that the diabetogenic effects of pregnancy are also expressed by Zimbabwean black women, especially in late gestation
Additional Citation InformationMakuyana, D., Mawji, K.G.D.,Ndlovu, S., Munyombwe, T.,Majoko, F. and Mahomed, K.(2005). Occurrence of diabetogenic changes in pregnancy among black women in an urban setting.Central African Journal of Medicine, 51 (9/10), 98-102.
University of Zimbabwe, College of Health Sciences