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    4-Aminoquinoline Prophylaxis of Malaria amongst Semi-Immune African School Children

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    Date
    1957-12
    Author
    Clyde, D.F.
    Shute, G.T.
    Type
    Article
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    Abstract
    Drugs used for the prophylaxis of malaria are generally recommended in doses sufficient to suppress the disease in persons without immunity, these amounts being considerably in excess of those required for the protection of indigenous inhabitants of malarious districts. Information is not generally available concerning the smallest useful doses of the 4-aminoquinoline series of suppressives amongst school children who possess a high degree of premunition, because treatment varies from place to place in relation to differing degrees of immunity and infection risk. It is the purpose of the trials described in this report to demonstrate dosages of amodiaquine and chloroquine just sufficient to prevent overt parasitaemia in children aged 6 to 15 years native to areas of holoendemic malaria transmission in East and Central Africa where Plasmodium falciparum predominates.
    Full Text Links
    Clyde, D.F. & Shute, G.T. (1957) 4-Aminoquinoline Prophylaxis of Malaria amongst Semi-Immune African School Children. CAJM vol. 3, no. 12. (pp. 496-498.) UZ (formerly University College Rhodesia), Harare (formerly Salisbury.) : Faculty of Medicine.
    0379-0622
    http://opendocs.ids.ac.uk/opendocs/handle/123456789/6604
    URI
    http://hdl.handle.net/10646/2245
    Publisher
    Faculty of Medicine, Central African Journal of Medicine (CAJM), University College of Rhodesia (now University of Zimbabwe)
    Subject
    Children and Youth
    Health
    xmlui.dri2xhtml.METS-1.0.item-rights
    http://creativecommons.org/licenses/by-nc-nd/3.0/

    University of Zimbabwe (UZ) (formerly University College of Rhodesia)
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