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An Experimental Pharmacokinetic Computer Program to Predict Potential Drug-Drug Interactions
(Bentham Open, 2008)
Polypharmacy as a result of combating co-infections, or combination therapy for better efficacy and reducing
the emergency of drug resistance, is on the increase in the African clinical setting in the advent of HIV/AIDS, ...
Genetic polymorphism of drug metabolizing enzymes in the Shona and the San in Zimbabwe and the clinical impact of CYP2D6 polymorphism on safety in the use of psychotropics
(2012-09-07)
INTRODUCTION: Interindividual variability to drug response is a well known
phenomenon and dates back to the 1950s with isoniazid. When the same dose of the same
drug is given to different individuals, some may respond ...
The Interaction of Antiparasitic Drugs with the Drug-metabolising Cytochrome P450s (CYPs) and Characterisation of a CYP Variant Unique to African Populations.
(2012-07-11)
The cytochrome P450 (CYP) superfamily of enzymes is now known to be an important determinant of the outcome of drug therapy. Consequently, drug-CYP interaction studies that have led to an improvement in production of safer ...
In Vitro interactionsof plant phenolic compounds and antiparasitic drugs with drug metabolising enzymes and transporters
(2012-07-11)
Drug metabolising enzymes and transporters play a critical role in the pharmacokinetics and hence, absorption, distribution, metabolism, and excretion (ADME) of compounds and medicines. The objective of this thesis was to ...