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The Interaction of Antiparasitic Drugs with the Drug-metabolising Cytochrome P450s (CYPs) and Characterisation of a CYP Variant Unique to African Populations.
(2012-07-11)
The cytochrome P450 (CYP) superfamily of enzymes is now known to be an important determinant of the outcome of drug therapy. Consequently, drug-CYP interaction studies that have led to an improvement in production of safer ...
In Vitro interactionsof plant phenolic compounds and antiparasitic drugs with drug metabolising enzymes and transporters
(2012-07-11)
Drug metabolising enzymes and transporters play a critical role in the pharmacokinetics and hence, absorption, distribution, metabolism, and excretion (ADME) of compounds and medicines. The objective of this thesis was to ...