The effect of a single low dose propofol at the end of the operation in reducing post operative nausea and vomiting ( PONV) in women undergoing laparoscopic gynaecological surgery at Parirenyatwa hospital.

Abstract

Objectives To determine the effectiveness of single low dose propofol in reducing PONV in women undergoing laparoscopic gynaecological surgery. To describe factors associated with nausea and vomiting in women undergoing laparoscopic gynaecological surgery. Study design: Randomized single blinded controlled study Setting: Parirenyatwa Hospital Subjects: Eighty women aged between 19-55 years booked for laparoscopic surgery. Statistical methods:Summary descriptive statistics, student’s t-test, and Chi-square test. Results: Incidence of nausea within one hour was 7.5% in the propofol group and 2.5% in the nonpropofol group (P = 0.6) and 10% and 15% nausea incidence after one hour in the respective groups. There were no reported incidences of vomiting after one hour from both study groups. Two participants from the propofol group (B) vomited within the first hour postoperatively and none from the nonpropofol group. Four participants (10.5%) complained of either nausea or vomiting from the propofol group compared to 9 (21.4%) from the non-propofol group (P = 0.23) which was not statistically significant. Conclusion: Administration of single low dose propofol 0.5mg/kg at the end of laparoscopic gynaecological surgery does not reduce the incidence of PONV after propofol (2mg/kg) induction.