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Group 2 Innate Lymphoid Cell Proportions Are Diminished in Young Helminth Infected Children and Restored by Curative Antihelminthic Treatment
Group 2 Innate lymphoid cells (ILC2s) are innate cells that produce the TH2 cytokines IL-5 and IL-13. The importance of these cells has recently been demonstrated in experimental models of parasitic diseases but there is ...
Regulatory and Activated T cells in human schistosoma haematobium infections
(PLoS One, 2011-02-10)
Acquired immunity against helminths is characterised by a complex interplay between the effector Th1 and Th2 immune responses and it slowly manifests with age as a result of cumulative exposure to parasite antigens. Data ...
Immunological consequences of antihelminthic treatment in preschool children exposed to urogenital schistosome infection
(Hindawi Publishing Corporation, 2013-05-13)
Urogenital schistosomiasis, due to Schistosoma haematobium, is endemic in sub-Saharan Africa. Control is by targeted treatment with praziquantel but preschool age children are excluded from control programs. Immunological ...
Investigating the inflammatory markers involved in Schistosoma haematobium protective immunity and susceptibility to infection
Schistosomiasis is a neglected tropical disease that affects more than 200 million people globally. In Zimbabwe, areas have been mapped that contain high S. haematobium morbidity. The effects are mostly felt in rural areas ...