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Regulatory and Activated T cells in human schistosoma haematobium infections
(PLoS One, 2011-02-10)
Acquired immunity against helminths is characterised by a complex interplay between the effector Th1 and Th2 immune responses and it slowly manifests with age as a result of cumulative exposure to parasite antigens. Data ...
Proportions of CD41 memory T cells are altered in individuals chronically infected with Schistosoma haematobium
(Nature Publishing Group, 2012-06-26)
Characterisation of protective helminth acquired immunity in humans or experimental models has focused on effector responses with little work conducted on memory responses. Here we show for the first time, that human ...
Group 2 Innate Lymphoid Cell Proportions Are Diminished in Young Helminth Infected Children and Restored by Curative Antihelminthic Treatment
(PLoS, 2015-03-20)
Group 2 Innate lymphoid cells (ILC2s) are innate cells that produce the TH2 cytokines IL-5 and IL-13. The importance of these cells has recently been demonstrated in experimental models of parasitic diseases but there is ...
Immunological consequences of antihelminthic treatment in preschool children exposed to urogenital schistosome infection
(Hindawi Publishing Corporation, 2013-05-13)
Urogenital schistosomiasis, due to Schistosoma haematobium, is endemic in sub-Saharan Africa. Control is by targeted treatment with praziquantel but preschool age children are excluded from control programs. Immunological ...
Identifying and evaluating field indicators of Urogenital Schistosomiasis-related morbidity in preschool-aged children
(PLOS, 2015-03-20)
Several studies have been conducted quantifying the impact of schistosome infections on health and development in school-aged children. In contrast, relatively little is known about morbidity levels in preschool-aged ...