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Group 2 Innate Lymphoid Cell Proportions Are Diminished in Young Helminth Infected Children and Restored by Curative Antihelminthic Treatment

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dc.contributor.author Nausch, Norman
dc.contributor.author Appleby, Laura J.
dc.contributor.author Sparks, Alexandra M.
dc.contributor.author Midzi, Nicholas
dc.contributor.author Mduluza, Takafira
dc.contributor.author Mutapi, Francisca
dc.date.accessioned 2016-07-08T07:40:37Z
dc.date.available 2016-07-08T07:40:37Z
dc.date.issued 2015-03-20
dc.identifier.citation Nausch N, Appleby LJ, Sparks AM, Midzi N, Mduluza T, Mutapi F (2015) Group 2 Innate Lymphoid Cell Proportions Are Diminished in Young Helminth Infected Children and Restored by Curative Anti-helminthic Treatment. PLoS Negl Trop Dis 9(3): e0003627. doi:10.1371/journal.pntd.0003627 en_US
dc.identifier.issn 1935-2727
dc.identifier.uri http://hdl.handle.net/10646/2724
dc.description.abstract Group 2 Innate lymphoid cells (ILC2s) are innate cells that produce the TH2 cytokines IL-5 and IL-13. The importance of these cells has recently been demonstrated in experimental models of parasitic diseases but there is a paucity of data on ILC2s in the context of human parasitic infections and in particular of the blood dwelling parasite Schistosoma haematobium. In this case-control study human peripheral blood ILC2s were analysed in relation to infection with the helminth parasite Schistosoma haematobium. Peripheral blood mononuclear cells of 36 S. haematobium infected and 36 age and sex matched uninfected children were analysed for frequencies of ILC2s identified as Lin-CD45+CD127+CD294+CD161+. ILC2s were significantly lower particularly in infected children aged 6–9 years compared to healthy participants. Curative anti-helminthic treatment resulted in an increase in levels of the activating factor TSLP and restoration of ILC2 levels. This study demonstrates that ILC2s are diminished in young helminth infected children and restored by removal of the parasites by treatment, indicating a previously undescribed association between a human parasitic infection and ILC2s and suggesting a role of ILC2s before the establishment of protective acquired immunity in human schistosomiasis. en_US
dc.description.sponsorship Wellcome Trust (Grant no WT082028MA; (http://www.wellcome. ac.uk) and Thrasher Research Fund (www.thrasherresearch.org) en_US
dc.language.iso en_ZW en_US
dc.publisher PLoS en_US
dc.subject Group 2 Innate lymphoid cells en_US
dc.subject parasitic diseases en_US
dc.subject Schistosoma haematobium en_US
dc.title Group 2 Innate Lymphoid Cell Proportions Are Diminished in Young Helminth Infected Children and Restored by Curative Antihelminthic Treatment en_US
dc.type Article en_US
dc.contributor.authoremail Norman.Nausch@med.uni-duesseldorf.de en_US


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