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Effects of Soy Isoflavone extract treatment on Morphology and Morphometry of the Urinary Tract of Overiectomised Female Sprague Dawley Rats

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dc.contributor.author Mwandiringana, Ellen
dc.date.accessioned 2014-07-17T06:30:18Z
dc.date.available 2014-07-17T06:30:18Z
dc.date.issued 2014-07-17
dc.identifier.uri http://hdl.handle.net/10646/1261
dc.description.abstract The effect of soy isoflavone extract on the morphology and morphometry of the urinary tract of ovariectomised Sprague Dwaley rats were evaluated using histological methods. Twenty four virgin adult Sprague Dawley rats were placed into three groups treated as follows: sham operate + distilled water, ovariectomy + soy isoflavone and ovariectomy + distilled water for 65 days. A 125μg isoflavone/g body weight/ day dosage was administered to the experimental group with ad libitum soy-free feed and water. The means for variables muscularis thickness, lamina propria thickness, muscle nuclei density, epithelium thickness and number of blood vessels were compared using ANOVA at 95% confidence interval. The sham operated group recorded significantly higher values for muscularis thickness and muscle nuclei density in all organs compared to the other two groups. Lamina propria thickness was lowest in the sham-vehicle treared group for all organs. No significant differences in the lamina propria thickness were recorded between the ovariectomy + isoflavone treated and the ovariectomy + distilled water treated groups in the urethra and bladder ( p=0.74; p=0.20) respectively. Urethral blood vessel numbers were significantly higher in the ovariectomy+ soy isoflavone group compared to the control groups (p=0.03). Ovariectomy resulted muscle depletion and vacuolation copled with an increase in lamina propria thickness in all organs. Soy isoflavones slightly reversed the effects of ovariectomy on muscle and connective tissue components of the bladder, urethra and ureter. Soy isoflavones were able to weakly positively influence the morphology and morphometry of the urinary tract. en_US
dc.language.iso en_ZW en_US
dc.subject Soy isoflavone extract en_US
dc.subject urinary tract en_US
dc.subject Sprague Dawley rats en_US
dc.title Effects of Soy Isoflavone extract treatment on Morphology and Morphometry of the Urinary Tract of Overiectomised Female Sprague Dawley Rats en_US
thesis.degree.advisor Ruziwa, S.D
thesis.degree.advisor Nkomozepi, P
thesis.degree.advisor Gori, E
thesis.degree.country Zimbabwe en_US
thesis.degree.discipline Preclinical Veterinary Studies en_US
thesis.degree.faculty Faculty of Veterinary Science en_US
thesis.degree.grantor University of Zimbabwe en_US
thesis.degree.grantoremail specialcol@uzlib.uz.ac.zw
thesis.degree.level MSc en_US
thesis.degree.name Master of Veterinary Science in Anatomy en_US
thesis.degree.thesistype Thesis en_US
dc.date.defense 2012-06


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