• Login
    View Item 
    •   UZ eScholar Home
    • Faculty of Science
    • Faculty of Science ETDs
    • Faculty of Science e-Theses Collection
    • View Item
    •   UZ eScholar Home
    • Faculty of Science
    • Faculty of Science ETDs
    • Faculty of Science e-Theses Collection
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Characterisation of signalling cascade by HBV genotypes in Hepatocellular Carcinoma progression

    Thumbnail
    View/Open
    Main article (1.388Mb)
    Date
    2018
    Author
    Matarise, Richard
    Metadata
    Show full item record

    Abstract
    Background Hepatitis B virus (HBV) genotypes have different clinical outcomes in the progression of hepatocellular carcinoma. The HBV encodes two regulatory proteins, the LHBs and the HBx. Methods We analysed the impact of the HBV genotypes A-D and G (GTA-GTG) regulatory proteins on the activation and induction of the Raf-MEK-MEK, Nrf2, NF‐κB and -taxilin pathways. Results We observed a genotype-specific activation and induction of the signalling pathways by the HBV genotypes regulatory proteins, which reflects differences in the impact of the HBV genotypes regulatory proteins and the progression of HCC in respect to the HBV genotypes. The cellular compartmentalization of the HBV regulatory proteins differs among the genotypes, which case impacts on the nuclei and cytosolic signals which are activated and induced. While reconstitution of HBVΔHBx with HBx revives the wildtype nature of HBV to produce viral particles, the produced viral particles of the reconstituted HBVΔHBx are not infective. Conclusion: Differences in the activation and induction of signalling pathways may result in the observed genotype-specific immunogenicity and pathogenesis of HBV genotypes.
    URI
    http://hdl.handle.net/10646/3883
    Additional Citation Information
    Matarise, R. (2018) Characterisation of signalling cascade by HBV genotypes in Hepatocellular Carcinoma progression. (Unpublished thesis). University of Zimbabwe.
    Sponsor
    The DAAD In-Country Zimbabwe Scholarship
    Subject
    HBVΔHBx
    NF‐κB
    Nrf2
    P-raf
    HBx
    LHBs
    HBV
    Collections
    • Faculty of Science e-Theses Collection [257]

    University of Zimbabwe: Educating To Change Lives!
    DSpace software copyright © 2002-2020  DuraSpace | Contact Us | Send Feedback
     

     

    Browse

    All of UZ eScholarCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    View Usage StatisticsView Google Analytics Statistics

    University of Zimbabwe: Educating To Change Lives!
    DSpace software copyright © 2002-2020  DuraSpace | Contact Us | Send Feedback